Our Research

Research Areas

Complement

The complement system is an evolutionary ancient immune defense mechanism, present in vertebrates and invertebrates. It forms a first line of defense in plasma and fluids surrounding tissues and enables the host to recognize and clear invading pathogens (bacteria and viruses) and altered host cells while protecting healthy host cells and tissues. In humans this system is formed by more than 30 large modular plasma proteins and cell surface receptors.

We study the complement system using a variety of biophysical techniques including X-ray Crystallography and Cryo-Electron Microscopy.

Membrane Proteins

Membrane proteins comprise 20-30% of proteins in the genome, but are targeted by over 50% of modern pharmaceuticals.

We study a number of membrane proteins using a variety of biophysical techniques including X-ray Crystallography and Cryo-Electron Microscopy.

Crystallographic Methods

We have worked on a variety of crystallographic methods for determining molecular structures or proteins with crystallography. These methods include:

Multi-dataset crystallographic methods, utilising multiple crystallographic datasets during structure solution

Ensemble Refinement, a method for combining Molecular Dynamics simulations with experimental diffraction data

Conditional Optimisation, a novel method for refinement, automated model building and ab initio phasing

Our Research

Research Areas

Complement

Membrane Proteins

Crystallographic Methods

Structure Gallery

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PDB Structures 6s08, 6s0a & 6s0b:

PDB Structures 6h15 & 6h16:

PDB Structures 6hcy & 6hd1:

PDB Structures 5o4g, 5o4o & 5o7p:

PDB Structure 6fcz:

PDB Structures 5nsc & 5nsg:

PDB Structure 5o35:

PDB Structure 5o32:

PDB Structures 5fo7, 5fo8,, 5fo9 & 5foa:

PDB Structure 5fob:

PDB Structures 4cdj & 4cdk:

PDB Structures 4cbn & 4cbo

PDB Structures 4bsu, 4bso, 4bsp, 4bsr, 4bss & 4bst:

PDB Structure 4aiw:

PDB Structure 4a5w:

PDB Structure 2xwj:

PDB Structures 2xwb, 2xwa & 2xw9:

PDB Structures 3ef3, 3esa, 3esb, 3esc & 3esd:

PDB Structures 3hrz & 3hs0:

PDB Structure 2wii:

PDB Structure 2win:

PDB Structure 3fid:

PDB Structure 2qqh:

PDB Structure 2qff:

PDB Structure 2qki:

PDB Structure 2ok5:

PDB Structure 2i07:

PDB Structures 2i6q & 2i6s:

PDB Structure 2erv:

PDB Structure 2a73:

PDB Structure 2a74:

PDB Structure 2brr:

PDB Structures 1uyo & 1uyn:

PDB Structure 1p4t:

PDB Structure 1m0u:

PDB Structures 1m10 & 1m0z:

PDB Structure 1kcm:

PDB Structure 1i78:

PDB Structure 1i8n:

PDB Structure 1fe8:

Protein structure videos

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Binding and activation of C1 to IgM platforms

Binding of C1 IgG1-Fc platforms

Alternative Pathway of Complement Activation

Model of C3 convertase activity

Conformational change from C3 to C3b

Structure of C3

Structure of C3b-FactorH Complex

Structure of FactorB